Drug-induced pancreatitis: An update - ScienceDirect.
The diagnosis of drug-induced pancreatitis is often challenging because there are no unique clinical characteristics to distinguish drugs from other causes of pancreatitis. The majority of cases.
Class I drugs include medications in which at least 1 case report described a recurrence of acute pancreatitis with a rechallenge with the drug. Class II drugs include drugs in which there is a consistent latency in 75% or more of the reported cases.
Badalov N, Baradarian R, Iswara K, Li J, Steinberg W, Tenner S. Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol. 2007;5(6):648-66117395548PubMed Google Scholar Crossref. 3. Singh S, Loke YK. Statins and pancreatitis: a systematic review of observational studies and spontaneous case reports. Drug Saf. 2006;29(12):1123-113217147459PubMed Google Scholar.
Hung WY et al. Contemporary review of drug-induced pancreatitis. CLASSIFICATION OF CAUSATIVE AGENTS It is difficult to determine if the effects are intrinsic for all members of a drug class despite reports of DIAP incidence within the class. Several classification systems have been proposed. A substantial number of medica-tions are known to cause AP, however, the underlying mechanism is still.
Ethanol-induced pancreatitis has different pathophysiological mechanisms. Studies have described that ethanol is a direct toxic insult to the acinar cell, causing inflammation and membrane destruction. Other mechanisms include sphincter of Oddi dysfunction, induction of hypertriglyceridaemia, or formation of free oxygen radicals.
Class Ia drugs are the drugs where all potential causes of acute pancreatitis such as gallstones, alcohol, hypertriglyceridemia, and medications were ruled out.
Drug-induced pancreatitis. Curr Gastroenterol Rep. 2012; 14(2):131-8 (ISSN: 1534. Definite proof for causality is defined by the WHO classification if symptoms reoccur upon rechallenge.In the actual algorithm the diagnosis is confirmed if no other cause of acute pancreatitis can be detected, and the patient is taking one of the suspected drugs. Major Subject Heading(s) Minor Subject Heading.